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Reference

Values and formulas

The exam hands you a lab sheet and expects the formulas. Knowing both cold is time you get back on every question that needs them.

Serum chemistry

  • Sodium

    136 to 146 mEq/L

    136 to 146 mmol/L

    Reflects free water balance, not sodium content. Correct by 1.6 mEq/L for every 100 mg/dL of glucose above normal.

  • Potassium

    3.5 to 5.0 mEq/L

    3.5 to 5.0 mmol/L

    Small serum changes reflect large total-body shifts, because most potassium is intracellular.

  • Chloride

    95 to 105 mEq/L

    95 to 105 mmol/L

  • Bicarbonate

    22 to 28 mEq/L

    22 to 28 mmol/L

  • Blood urea nitrogen

    7 to 18 mg/dL

    2.5 to 6.4 mmol/L

    A ratio to creatinine above 20:1 suggests a prerenal cause.

  • Creatinine

    0.6 to 1.2 mg/dL

    53 to 106 umol/L

    An insensitive early marker: filtration can fall by half before it leaves the normal range.

  • Glucose, fasting

    70 to 100 mg/dL

    3.8 to 5.6 mmol/L

  • Calcium, total

    8.4 to 10.2 mg/dL

    2.1 to 2.6 mmol/L

    Correct for albumin, or the value misleads in liver disease and nephrosis.

  • Magnesium

    1.5 to 2.0 mEq/L

    0.75 to 1.0 mmol/L

    Low magnesium makes hypokalemia and hypocalcemia refractory until it is replaced.

  • Phosphorus

    3.0 to 4.5 mg/dL

    1.0 to 1.5 mmol/L

    Moves opposite to calcium under parathyroid hormone.

  • Total protein

    6.0 to 7.8 g/dL

    60 to 78 g/L

  • Albumin

    3.5 to 5.5 g/dL

    35 to 55 g/L

    The main determinant of plasma oncotic pressure.

  • Bilirubin, total

    0.1 to 1.0 mg/dL

    2 to 17 umol/L

  • Bilirubin, direct

    0.0 to 0.3 mg/dL

    0 to 5 umol/L

    The conjugated fraction. Elevated in obstruction and hepatocellular disease, normal in hemolysis and Gilbert syndrome.

  • Aspartate aminotransferase

    8 to 20 U/L

    A ratio to alanine aminotransferase above 2:1 suggests alcoholic liver disease.

  • Alanine aminotransferase

    8 to 20 U/L

    More liver-specific than aspartate aminotransferase.

  • Alkaline phosphatase

    20 to 70 U/L

    Also rises from bone and placenta; gamma-glutamyl transferase separates the sources.

  • Amylase

    25 to 125 U/L

  • Lipase

    14 to 280 U/L

    More specific for pancreatitis than amylase and stays elevated longer.

  • Uric acid

    3.0 to 8.2 mg/dL

    0.18 to 0.48 mmol/L

  • Cholesterol, total

    Below 200 mg/dL desirable

    Below 5.2 mmol/L

  • Triglycerides

    Below 150 mg/dL

    Below 1.7 mmol/L

    Above roughly 1000 mg/dL, pancreatitis becomes a real risk.

  • Osmolality

    275 to 295 mOsm/kg

    Compare measured with calculated to find an osmolar gap.

  • Creatine kinase

    Male 25 to 90 U/L, female 10 to 70 U/L

  • Troponin I

    Below 0.04 ng/mL

    Rises about 3 hours after myocardial injury and stays elevated for days.

  • Lactate dehydrogenase

    45 to 200 U/L

    Non-specific. Rises in hemolysis, tumour lysis and Pneumocystis pneumonia.

Hematologic

  • Hemoglobin

    Male 13.5 to 17.5 g/dL, female 12.0 to 16.0 g/dL

  • Hematocrit

    Male 41 to 53 percent, female 36 to 46 percent

  • Mean corpuscular volume

    80 to 100 fL

    The first branch point in any anemia: below 80 microcytic, above 100 macrocytic.

  • Leukocyte count

    4,500 to 11,000/mm3

  • Platelet count

    150,000 to 400,000/mm3

    Spontaneous bleeding is uncommon above 20,000.

  • Reticulocyte count

    0.5 to 1.5 percent

    Correct for anemia before interpreting; it separates production failure from destruction.

  • Erythrocyte sedimentation rate

    Male 0 to 15 mm/h, female 0 to 20 mm/h

    Above 50 with a new headache in an older patient should prompt thinking about giant cell arteritis.

  • Prothrombin time

    11 to 15 seconds

    The extrinsic pathway. Prolonged first in vitamin K deficiency and liver disease, because factor VII has the shortest half-life.

  • Partial thromboplastin time

    25 to 40 seconds

    The intrinsic pathway. A mixing study separates a missing factor from an inhibitor.

  • Ferritin

    Male 20 to 250 ng/mL, female 10 to 120 ng/mL

    The single most useful iron study, but it is an acute phase reactant and rises with inflammation.

  • Iron

    50 to 170 ug/dL

  • Total iron-binding capacity

    250 to 400 ug/dL

    Rises in true iron deficiency and falls in anemia of chronic disease.

  • Vitamin B12

    200 to 800 pg/mL

    When borderline, methylmalonic acid settles it.

  • Folate

    2.5 to 20 ng/mL

Arterial blood gas

  • pH

    7.35 to 7.45

    Decide the primary disturbance from the direction of the pH, then check whether compensation is appropriate.

  • PaO2

    75 to 105 mm Hg

  • PaCO2

    33 to 45 mm Hg

    Set entirely by alveolar ventilation.

  • Bicarbonate, arterial

    22 to 28 mEq/L

  • Oxygen saturation

    95 to 100 percent

    Normal in carbon monoxide poisoning on pulse oximetry, which is the trap.

Cerebrospinal fluid

  • Opening pressure

    70 to 180 mm H2O

  • Glucose, CSF

    40 to 70 mg/dL

    Interpret against a simultaneous serum glucose; the normal ratio is about two-thirds. Low means bacteria, mycobacteria or fungi.

  • Protein, CSF

    Below 40 mg/dL

    Raised with few cells is albuminocytologic dissociation, the pattern in Guillain-Barre syndrome.

  • Leukocytes, CSF

    0 to 5 cells/mm3

    Neutrophil predominance suggests bacteria, lymphocytic suggests viral, mycobacterial or fungal.

Urine

  • Specific gravity

    1.003 to 1.030

    Maximally dilute urine in the face of hypernatremia points at diabetes insipidus.

  • Osmolality, urine

    50 to 1200 mOsm/kg

  • Protein, 24 hour

    Below 150 mg/24 h

    Above 3.5 g/24 h is nephrotic range.

  • Creatinine clearance

    Male 97 to 137 mL/min, female 88 to 128 mL/min

Endocrine

  • Thyroid-stimulating hormone

    0.4 to 4.0 uU/mL

    The most sensitive early marker of thyroid dysfunction: it moves before free thyroxine does.

  • Thyroxine, free

    0.9 to 1.7 ng/dL

  • Cortisol, 8 AM

    5 to 23 ug/dL

    A single random value is uninterpretable because of the diurnal rhythm.

  • Parathyroid hormone

    10 to 60 pg/mL

    Interpret only alongside calcium; the pair is what makes the diagnosis.

  • Hemoglobin A1c

    Below 5.7 percent

    Reflects roughly three months of glycemia, the lifespan of a red cell. Misleads in hemolysis and recent transfusion.

Reference ranges vary between laboratories. These are the conventional adult ranges in the form the exam presents them, and a real report should always be read against the range printed on it. Nothing here is medical advice.